For members of the Interdisciplinary Affective Science Laboratory, it means that we study psychology, but take a different approach from many other psychology labs. We start from first principles in biology, physiology, and neuroscience (e.g., brain evolution, development, structure and metabolics) and then ask how that brain—in constant conversation with its body and the surrounding world—manifests emotions, cognitions, perceptions, actions, and other features of a mind. The resulting hypotheses transcend the boundaries of any single discipline and can seem counterintuitive from a traditional perspective. We dissolve some old debates and ask different (and more generative) questions across a range of domains with relevance to a range of disciplines.